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Scientist/Senior Scientist, Bioanalytical

Company: Avidity Biosciences, Inc.
Location: Antioch
Posted on: January 27, 2023

Job Description:

We are seeking an experienced scientist to join the Development Sciences team at Avidity Biosciences in San Diego, CA. -This position will reside within the Bioanalytical Sciences (BA) group with responsibility for developing bioanalytical assays for research and development programs. The ideal candidate will be able to independently develop novel methods for quantifying the analytes of interest, lead projects and mentor team members. -This position will require hands on laboratory experience and a successful track record of developing bioanalytical assays for preclinical and clinical drug candidates. Additional responsibilities include representing the BA function on research teams, mentoring research associates, responsible for processing and analyzing samples, among others. -This position will also require transfer of these methods to external service providers (CROs), as well as translation of the methods into human matrix to support clinical studies. -We seek a candidate who enjoys scientific discovery, is team oriented and possess excellent communication skills that excels in a collaborate fast-paced interdisciplinary environment.
--- -Responsibilities: - - - - - - - - -Design and develop of novel methods for measurement of drug candidates in plasma & tissue to support pre-clinical and clinical programs. - - - - - - - - -Design and perform experiments, analyze experimental data, interpret results, troubleshoot assays, and guide appropriate next steps - - - - - - - - - -Lead bioanalytical technical discussion for more than one program - - - - - - - - -Collaborate and communicate across departments, participate on drug development project teams, and function as a bridge between pre-clinical and clinical development - - - - - - - - -Manage relationships with external service providers - - - - - - - - -Demonstrate effective presentation and verbal communication at internal meetings as well as clear written communication - - - - - - - - -Mentor associate scientists and junior team members.
Qualifications: - - - - - - - - -PhD in Biochemistry, Bioengineering, Biology, Chemistry, or related discipline with 2+ years of postdoctoral and/or industry experience - - - - - - - - -Extensive knowledge and hands on experience of bioanalytical assay development for large molecule (ex. Antibody, Protein, Oligos---) on Triple quad. and/or high-resolution Mass Spectrometry is required. - - - - - - - - -Method development experience with bioanalytical assays supporting protein and/or RNA therapeutics on LC-MS/MS or HRMS is required. - - - - - - - - -Demonstrated ability to troubleshoot bioanalytical assays is required. - - - - - - - - -Demonstrated ability to lead projects/programs is required. - - - - - - - - -Experience developing bioanalytical assays across multiple platforms is desired. - - - - - - - - -Hands-on lab experience with various laboratory techniques including, Nanostring, qPCR, ELISA, MSD (for PK and ADA assays) cell culture, RNA isolation is a plus. - - - - - - - - -Clinical bioanalytical experience is highly desired. - - - - - - - - -Experience working with external contract labs is a plus. - - - - - - - - -Experience with GxP bioanalytical assays is a plus. - - - - - - - - -Knowledge on various in-vitro & in-vivo bioanalytical assays to support drug metabolism (DMPK) is a plus. - - - - - - - - -Ability to conduct self-directed research and to work effectively in a dynamic environment with a diverse team of coworkers. - - - - - - - - -Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.

Keywords: Avidity Biosciences, Inc., Antioch , Scientist/Senior Scientist, Bioanalytical, Other , Antioch, California

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