Scientist/Senior Scientist, Bioanalytical
Company: Avidity Biosciences, Inc.
Location: Antioch
Posted on: January 27, 2023
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Job Description:
We are seeking an experienced scientist to join the Development
Sciences team at Avidity Biosciences in San Diego, CA. -This
position will reside within the Bioanalytical Sciences (BA) group
with responsibility for developing bioanalytical assays for
research and development programs. The ideal candidate will be able
to independently develop novel methods for quantifying the analytes
of interest, lead projects and mentor team members. -This position
will require hands on laboratory experience and a successful track
record of developing bioanalytical assays for preclinical and
clinical drug candidates. Additional responsibilities include
representing the BA function on research teams, mentoring research
associates, responsible for processing and analyzing samples, among
others. -This position will also require transfer of these methods
to external service providers (CROs), as well as translation of the
methods into human matrix to support clinical studies. -We seek a
candidate who enjoys scientific discovery, is team oriented and
possess excellent communication skills that excels in a collaborate
fast-paced interdisciplinary environment.
--- -Responsibilities: - - - - - - - - -Design and develop of novel
methods for measurement of drug candidates in plasma & tissue to
support pre-clinical and clinical programs. - - - - - - - - -Design
and perform experiments, analyze experimental data, interpret
results, troubleshoot assays, and guide appropriate next steps - -
- - - - - - - -Lead bioanalytical technical discussion for more
than one program - - - - - - - - -Collaborate and communicate
across departments, participate on drug development project teams,
and function as a bridge between pre-clinical and clinical
development - - - - - - - - -Manage relationships with external
service providers - - - - - - - - -Demonstrate effective
presentation and verbal communication at internal meetings as well
as clear written communication - - - - - - - - -Mentor associate
scientists and junior team members.
Qualifications: - - - - - - - - -PhD in Biochemistry,
Bioengineering, Biology, Chemistry, or related discipline with 2+
years of postdoctoral and/or industry experience - - - - - - - -
-Extensive knowledge and hands on experience of bioanalytical assay
development for large molecule (ex. Antibody, Protein, Oligos---)
on Triple quad. and/or high-resolution Mass Spectrometry is
required. - - - - - - - - -Method development experience with
bioanalytical assays supporting protein and/or RNA therapeutics on
LC-MS/MS or HRMS is required. - - - - - - - - -Demonstrated ability
to troubleshoot bioanalytical assays is required. - - - - - - - -
-Demonstrated ability to lead projects/programs is required. - - -
- - - - - -Experience developing bioanalytical assays across
multiple platforms is desired. - - - - - - - - -Hands-on lab
experience with various laboratory techniques including,
Nanostring, qPCR, ELISA, MSD (for PK and ADA assays) cell culture,
RNA isolation is a plus. - - - - - - - - -Clinical bioanalytical
experience is highly desired. - - - - - - - - -Experience working
with external contract labs is a plus. - - - - - - - - -Experience
with GxP bioanalytical assays is a plus. - - - - - - - - -Knowledge
on various in-vitro & in-vivo bioanalytical assays to support drug
metabolism (DMPK) is a plus. - - - - - - - - -Ability to conduct
self-directed research and to work effectively in a dynamic
environment with a diverse team of coworkers. - - - - - - - -
-Solid written and oral communication skills, enthusiasm,
integrity, self-motivation, strong interpersonal skills, and
attention to detail are necessary.
Keywords: Avidity Biosciences, Inc., Antioch , Scientist/Senior Scientist, Bioanalytical, Other , Antioch, California
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